CEP250

Across TCGA pan-cancer cohorts, CEP250 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CEP250’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CEP250 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CEP250 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where CEP250 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CEP250 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.100	<.001	11	view →
KIRP	All	II,III,IV	+1.093	<.001	11	view →
KIRC	Male	IV	+1.062	<.001	11	view →
COAD	All	IV	+1.147	<.001	10	view →
LIHC	Female	II,III,IV	+1.430	<.001	9	view →
LUAD	Male	All	+0.901	<.001	9	view →
BLCA	All	All	+0.648	<.001	9	view →
STAD	Male	II,III,IV	+1.233	<.001	8	view →
LUSC	Female	All	+1.164	<.001	7	view →
BRCA	All	II,III,IV	+0.497	<.001	6	view →
UCEC	All	All	+0.489	.001	6	view →
CHOL	Male	All	+2.136	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CEP250–HNSC

Open the HNSC breakdown →