CENPU

Across TCGA patient cohorts, CENPU mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPU-associated genes across cancer lineages are ASNS, Cyclin-B1, and EGFR_pY1068. Each is linked with CENPU in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPU-to-partner and partner-to-CENPU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CENPU-low versus CENPU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPU→partner) and Y-score (partner→CENPU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.569	+2.459	<.001	.019	3	2
UCEC	Cyclin-B1 →	+0.854	+2.807	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.115	.019	.019	3	1
UCEC	A-Raf_pS299 →	-0.127	-3.321	.014	.010	3	1
UCEC	JNK2 →	+0.210	+3.026	.015	.018	3	1
UCEC	MEK1 →	+0.455	+3.584	.004	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ASNS by CENPU expression — UCEC

Explore this box plot interactively →