CENPT

Across TCGA patient cohorts, CENPT mutation is significantly associated with the RNA expression of many other genes, with 1,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPT-associated genes across cancer lineages are MIR4688, ZNF736P7Y, and SNORD116-10. Each is linked with CENPT in more than 2 cancer types. Because this analysis shows association rather than direction, both CENPT-to-partner and partner-to-CENPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4688 grouped by CENPT-low versus CENPT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPT→partner) and Y-score (partner→CENPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4688 →	+0.457	+5.224	<.001	<.001	3	3
HNSC	ZNF736P7Y →	+0.092	+5.015	<.001	.009	3	3
LUSC	SNORD116-10 →	+0.274	+5.517	<.001	.001	3	3
HNSC	OR1E3 →	+0.064	+5.182	<.001	.007	3	2
HNSC	MIR920 →	+0.747	+5.124	<.001	.008	3	2
HNSC	RNA5SP115 →	+0.465	+5.303	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

MIR4688 by CENPT expression — SKCM

Explore this box plot interactively →