CENPT

Across TCGA pan-cancer cohorts, CENPT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CENPT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CENPT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CENPT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where CENPT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.810	<.001	12	view →
THCA	All	IV	−0.779	<.001	11	view →
KIRC	Male	IV	+0.596	<.001	11	view →
COAD	Female	All	+0.969	<.001	10	view →
LIHC	Female	II,III,IV	+1.181	<.001	9	view →
KICH	Female	All	−0.993	<.001	7	view →
KIRP	All	II,III,IV	+0.641	.003	7	view →
BRCA	Female	All	−0.594	<.001	6	view →
CHOL	Male	All	+2.191	<.001	5	view →
STAD	Male	II,III,IV	+0.589	.009	5	view →
BLCA	All	All	+0.389	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CENPT–HNSC

Open the HNSC breakdown →