CENPT

Across TCGA pan-cancer cohorts, CENPT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CENPT data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CENPT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPT expression acts as an unfavorable survival marker, although some lineages such as PAAD and THYM show a favorable association.

KIRC, ACC, and PAAD are the cancer types where CENPT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.517	0.703	<.001	99	view →
ACC	OS	Median	All	0.359	0.836	<.001	89	view →
PAAD	OS	Median	II,III,IV	0.508	0.265	<.001	37	view →
COAD	OS	Quartile	All	0.399	0.737	<.001	36	view →
LIHC	DFS	Tertile	All	0.434	0.614	<.001	33	view →
THYM	DFS	Tertile	All	0.886	0.440	.002	27	view →
PRAD	DFS	Median	All	0.669	0.893	<.001	24	view →
MESO	DFS	Median	IV	0.193	0.489	.012	21	view →
SKCM	OS	Median	All	0.816	0.908	.008	21	view →
LUSC	DFS	Median	II,III,IV	0.612	0.861	.005	19	view →
ESCA	DFS	Tertile	IV	0.704	0.231	.024	12	view →
LGG	DFS	Quartile	All	0.762	0.867	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CENPT–KIRC (DFS)

Open the KIRC breakdown →