CENPT

Across TCGA patient cohorts, CENPT mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPT-associated genes across cancer lineages are A-Raf_pS299, 4E-BP1, and EGFR_pY1068. Each is linked with CENPT in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPT-to-partner and partner-to-CENPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CENPT-low versus CENPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPT→partner) and Y-score (partner→CENPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.154	-3.000	.007	.036	3	2
UCEC	4E-BP1 →	+0.430	+2.999	.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.287	-3.584	.018	.002	3	1
UCEC	Fibronectin →	-0.350	-3.160	.028	.019	3	1
UCEC	Heregulin →	-0.141	-3.000	.018	.036	3	1
UCEC	JNK2 →	+0.308	+2.834	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by CENPT expression — UCEC

Explore this box plot interactively →