CENPT

Across TCGA cell cohorts, CENPT mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPT-associated genes across cancer lineages are RFX4, TBC1D21, and OR10W1. Each is linked with CENPT in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPT-to-partner and partner-to-CENPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFX4 grouped by CENPT-low versus CENPT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPT→partner) and Y-score (partner→CENPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFX4 →	+0.046	+3.766	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
BLOOD_Leukemia	CPXCR1 →	+0.068	+3.971	<.001	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.023	+3.475	<.001	.006	3	1
BLOOD_Leukemia	FOXS1 →	+0.051	+3.949	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RFX4 by CENPT expression — LARGE_INTESTINE

Explore this box plot interactively →