CENPS-CORT

Across TCGA patient cohorts, CENPS-CORT mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPS-CORT-associated genes across cancer lineages are RNU5E-9P, SDR42E1P2, and KLF17P2. Each is linked with CENPS-CORT in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPS-CORT-to-partner and partner-to-CENPS-CORT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5E-9P grouped by CENPS-CORT-low versus CENPS-CORT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPS-CORT→partner) and Y-score (partner→CENPS-CORT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU5E-9P →	+0.314	+4.010	<.001	.007	3	2
BRCA	SDR42E1P2 →	+0.079	+8.055	<.001	.007	3	1
HNSC	KLF17P2 →	+0.089	+7.954	<.001	.008	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
SKCM	RNU1-20P →	+0.218	+4.513	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

RNU5E-9P by CENPS-CORT expression — UCEC

Explore this box plot interactively →