CENPS-CORT

Across TCGA pan-cancer cohorts, CENPS-CORT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CENPS-CORT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CENPS-CORT RNA is repressed in tumor relative to normal tissue. In most cancer types CENPS-CORT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where CENPS-CORT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPS-CORT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.182	<.001	11	view →
BLCA	All	All	+0.562	<.001	10	view →
THCA	Male	IV	−0.886	<.001	9	view →
STAD	All	All	+0.343	<.001	7	view →
HNSC	Male	III,IV	+0.273	.001	7	view →
BRCA	All	All	+0.241	<.001	6	view →
LIHC	Male	All	+0.191	<.001	6	view →
LUSC	All	All	+0.338	<.001	5	view →
KIRC	Male	All	−0.246	<.001	5	view →
KIRP	All	All	−0.296	<.001	4	view →
CHOL	All	All	+0.510	<.001	3	view →
LUAD	All	All	+0.179	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CENPS-CORT–KICH

Open the KICH breakdown →