CENPS-CORT

Across TCGA pan-cancer cohorts, CENPS-CORT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CENPS-CORT data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CENPS-CORT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CENPS-CORT expression acts as an unfavorable survival marker, although some lineages such as CESC and KIRP show a favorable association.

UVM, ACC, and LIHC are the cancer types where CENPS-CORT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.442	0.819	<.001	107	view →
ACC	OS	Tertile	All	0.755	0.974	<.001	71	view →
LIHC	DFS	Median	All	0.343	0.516	<.001	57	view →
KICH	OS	Median	All	0.668	1.000	.002	48	view →
LGG	DFS	Median	All	0.674	0.801	<.001	34	view →
UCS	DFS	Tertile	IV	0.237	0.975	.024	24	view →
CESC	OS	Quartile	All	0.758	0.495	.016	24	view →
SARC	OS	Tertile	All	0.693	0.917	.003	22	view →
ESCA	DFS	Quartile	III,IV	0.262	0.574	.001	18	view →
KIRP	DFS	Median	All	0.900	0.612	.011	18	view →
THYM	DFS	Median	All	0.972	0.834	.004	17	view →
KIRC	DFS	Quartile	All	0.786	0.534	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CENPS-CORT–UVM (OS)

Open the UVM breakdown →