CENPS-CORT

Across TCGA patient cohorts, CENPS-CORT mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPS-CORT-associated genes across cancer lineages are FOXO3a_pS318_S321, p38-MAPK_pT180_Y182, and PCNA. Each is linked with CENPS-CORT in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPS-CORT-to-partner and partner-to-CENPS-CORT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CENPS-CORT-low versus CENPS-CORT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPS-CORT→partner) and Y-score (partner→CENPS-CORT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.138	-3.169	.044	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.584	-3.000	.018	.036	3	1
UCEC	PCNA →	+0.269	+3.169	.023	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.445	-3.169	.003	.020	3	1
UCEC	Annexin-1 →	+0.689	+3.169	.017	.020	3	1
UCEC	MEK1 →	+0.476	+3.169	.017	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a_pS318_S321 by CENPS-CORT expression — UCEC

Explore this box plot interactively →