CENPC

Across TCGA patient cohorts, CENPC mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPC-associated genes across cancer lineages are 14-3-3_beta, p62 Lck ligand, and ASNS. Each is linked with CENPC in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPC-to-partner and partner-to-CENPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CENPC-low versus CENPC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPC→partner) and Y-score (partner→CENPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.071	-1.738	.013	.011	3	2
UCEC	p62 Lck ligand →	+0.330	+1.954	<.001	<.001	3	2
UCEC	ASNS →	+0.385	+1.514	<.001	.012	3	2
UCEC	Caspase-7-cleavedD198 →	+0.535	+1.534	.001	.008	3	2
UCEC	cIAP →	+0.101	+1.746	.010	.003	3	2
UCEC	4E-BP1 →	+0.316	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by CENPC expression — UCEC

Explore this box plot interactively →