CENPC

Across TCGA cell cohorts, CENPC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,340 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPC-associated GO terms across cancer lineages are Meiotic metaphase chromosome alignment, Protein modification by small protein removal, and Microtubule organizing center organization. Each is linked with CENPC in more than 19 cancer types. Because this analysis shows association rather than direction, both CENPC-to-partner and partner-to-CENPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic metaphase chromosome alignment grouped by CENPC-low versus CENPC-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPC→partner) and Y-score (partner→CENPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Meiotic metaphase chromosome alignment →	+0.154	+1.025	<.001	<.001	3	20
LUNG_SCLC	Protein modification by small protein removal →	+0.054	+0.763	.003	.002	3	18
URINARY_TRACT	Microtubule organizing center organization →	+0.093	+0.987	<.001	.002	3	17
URINARY_TRACT	Centrosome cycle →	+0.095	+0.987	<.001	.002	3	17
URINARY_TRACT	Centriole replication →	+0.118	+1.005	<.001	.002	3	17
OVARY	Positive regulation of organelle assembly →	+0.069	+1.039	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,340 associations by consensus.

Meiotic metaphase chromosome alignment by CENPC expression — BLOOD_Lymphoma

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