CELF5

Across TCGA patient cohorts, CELF5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELF5-associated genes across cancer lineages are MSH2, STAT5a, and BRCA2. Each is linked with CELF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CELF5-to-partner and partner-to-CELF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by CELF5-low versus CELF5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELF5→partner) and Y-score (partner→CELF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MSH2 →	-0.310	-2.982	.014	.036	1	3
UCEC	STAT5a →	+0.578	+3.169	.008	.020	2	1
UCEC	BRCA2 →	-0.154	-2.989	.027	.035	2	1
SKCM	Caveolin-1 →	+0.761	+3.000	.032	.036	1	2
UCEC	GAPDH →	+0.674	+3.169	.022	.020	1	1
UCEC	Di-Ras3 →	-0.217	-3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSH2 by CELF5 expression — SKCM

Explore this box plot interactively →