CEBPE

Across TCGA patient cohorts, CEBPE mutation is significantly associated with the RNA expression of many other genes, with 770 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEBPE-associated genes across cancer lineages are RNU6-119P, GRPEL2, and PBK. Each is linked with CEBPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CEBPE-to-partner and partner-to-CEBPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-119P grouped by CEBPE-low versus CEBPE-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEBPE→partner) and Y-score (partner→CEBPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNU6-119P →	+0.320	+5.384	.004	.005	3	2
UCEC	GRPEL2 →	+0.526	+3.374	.003	.004	3	2
UCEC	PBK →	+0.824	+2.233	.008	.006	3	2
UCEC	MTIF2 →	+0.458	+2.928	.004	.001	3	2
UCEC	ANKHD1 →	+0.239	+2.928	.007	.001	3	2
UCEC	RNF14 →	+0.551	+2.971	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

RNU6-119P by CEBPE expression — OV

Explore this box plot interactively →