CEBPE

Across TCGA pan-cancer cohorts, CEBPE RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CEBPE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CEBPE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CEBPE is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where CEBPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CEBPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.249	<.001	11	view →
HNSC	Male	All	+0.763	<.001	10	view →
THCA	All	III,IV	+0.195	.007	6	view →
BRCA	Female	All	+0.099	<.001	6	view →
LUSC	Male	II,III,IV	−0.435	<.001	5	view →
LUAD	All	II,III,IV	−0.237	.002	4	view →
UCEC	All	III,IV	−0.134	.017	4	view →
PAAD	All	All	−0.679	.047	2	view →
KIRP	All	All	+0.196	.011	2	view →
CHOL	Male	All	+0.113	.033	2	view →
KICH	All	II,III,IV	−0.077	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CEBPE–KIRC

Open the KIRC breakdown →