CEBPE

Across TCGA patient cohorts, CEBPE mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEBPE-associated genes across cancer lineages are STAT3_pY705, FASN, and Ku80. Each is linked with CEBPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CEBPE-to-partner and partner-to-CEBPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CEBPE-low versus CEBPE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEBPE→partner) and Y-score (partner→CEBPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.458	-3.584	<.001	.002	3	2
UCEC	FASN →	+0.377	+2.459	.047	.020	3	1
UCEC	Ku80 →	+0.253	+2.820	.026	.035	3	1
UCEC	Rad50 →	-0.239	-2.459	.041	.020	3	1
UCEC	S6_pS240_S244 →	+0.396	+2.459	.043	.020	3	1
UCEC	TFRC →	+0.672	+3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

STAT3_pY705 by CEBPE expression — UCEC

Explore this box plot interactively →