CEBPE

Across TCGA cell cohorts, CEBPE mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEBPE-associated genes across cancer lineages are OR1L3, MDFIC2, and PCCB. Each is linked with CEBPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CEBPE-to-partner and partner-to-CEBPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by CEBPE-low versus CEBPE-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEBPE→partner) and Y-score (partner→CEBPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PCCB →	+0.751	+3.125	<.001	.008	3	1
LARGE_INTESTINE	FGF23 →	+0.574	+3.807	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	CALML5 →	+0.637	+3.241	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR1L3 by CEBPE expression — SKIN

Explore this box plot interactively →