CEBPA

Across TCGA patient cohorts, CEBPA mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEBPA-associated genes across cancer lineages are SNORD114-15, MIR378G, and MIR4672. Each is linked with CEBPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CEBPA-to-partner and partner-to-CEBPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-15 grouped by CEBPA-low versus CEBPA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEBPA→partner) and Y-score (partner→CEBPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD114-15 →	+0.398	+7.640	<.001	.009	3	1
UCEC	MIR378G →	+0.919	+2.996	.001	.009	3	1
UCEC	MIR4672 →	+0.557	+3.041	.002	.008	3	1
UCEC	MIR4764 →	+0.535	+4.811	<.001	<.001	3	1
UCEC	RNF138P2 →	+0.081	+4.260	.001	.007	3	1
UCEC	MIR6780A →	+0.750	+3.386	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

SNORD114-15 by CEBPA expression — BLCA

Explore this box plot interactively →