CEBPA

Across TCGA pan-cancer cohorts, CEBPA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CEBPA data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CEBPA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CEBPA expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where CEBPA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.747	0.554	<.001	76	view →
SKCM	OS	Median	II,III,IV	0.424	0.215	.001	75	view →
LUAD	OS	Tertile	All	0.866	0.731	<.001	55	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	55	view →
LGG	DFS	Median	All	0.676	0.796	<.001	48	view →
UCEC	DFS	Quartile	All	0.867	0.941	.002	30	view →
MESO	OS	Median	All	0.633	0.469	.007	27	view →
SARC	OS	Quartile	All	0.834	0.604	.001	25	view →
KIRP	OS	Median	II,III,IV	0.757	0.314	.004	23	view →
LUSC	DFS	Median	II,III,IV	0.683	0.494	.005	19	view →
PAAD	DFS	Quartile	II,III,IV	0.522	0.319	.005	16	view →
READ	OS	Quartile	All	1.000	0.590	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CEBPA–HNSC (DFS)

Open the HNSC breakdown →