CDKN2D

Across TCGA cell cohorts, CDKN2D mutation is significantly associated with the mutation status of many other genes, with 3,505 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKN2D-associated genes across cancer lineages are CDH15, SH3BP4, and USHBP1. Each is linked with CDKN2D in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN2D-to-partner and partner-to-CDKN2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH15 grouped by CDKN2D-low versus CDKN2D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2D→partner) and Y-score (partner→CDKN2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH15 →	+3.159	+4.632	<.001	<.001	1	2
LARGE_INTESTINE	SH3BP4 →	+3.007	+3.584	.008	.008	1	2
BLOOD_Leukemia	USHBP1 →	+4.157	+5.430	<.001	<.001	1	2
LARGE_INTESTINE	FIBCD1 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	UBE2M →	+4.329	+4.329	.001	.001	1	2
BLOOD_Leukemia	ATG4D →	+4.894	+4.894	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

CDH15 by CDKN2D expression — LARGE_INTESTINE

Explore this box plot interactively →