CDKN2D

Across TCGA pan-cancer cohorts, CDKN2D RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CDKN2D data layer compared with 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CDKN2D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CDKN2D expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

KICH, ACC, and LIHC are the cancer types where CDKN2D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.529	1.000	<.001	102	view →
ACC	DFS	Tertile	All	0.185	0.665	<.001	73	view →
LIHC	DFS	Median	All	0.457	0.622	<.001	63	view →
MESO	OS	Tertile	II,III,IV	0.279	0.576	<.001	57	view →
KIRP	DFS	Tertile	All	0.419	0.893	.002	53	view →
HNSC	DFS	Median	All	0.755	0.662	.015	38	view →
KIRC	DFS	Quartile	III,IV	0.821	0.531	.008	24	view →
CESC	OS	Quartile	All	0.858	0.687	.011	20	view →
PRAD	DFS	Tertile	All	0.898	0.957	.003	18	view →
THYM	OS	Median	II,III,IV	0.962	0.682	.003	17	view →
READ	OS	Median	All	0.357	0.814	.013	15	view →
LAML	DFS	Median	All	0.454	0.681	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CDKN2D–KICH (OS)

Open the KICH breakdown →