CDKN1C

Across TCGA patient cohorts, CDKN1C mutation is significantly associated with the RNA expression of many other genes, with 197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1C-associated genes across cancer lineages are CXADR, GATAD1, and UBR1. Each is linked with CDKN1C in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1C-to-partner and partner-to-CDKN1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXADR grouped by CDKN1C-low versus CDKN1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1C→partner) and Y-score (partner→CDKN1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXADR →	+0.825	+3.470	.008	.003	3	1
UCEC	GATAD1 →	+0.587	+3.499	.002	.002	3	1
UCEC	UBR1 →	+0.635	+3.459	.003	.005	3	1
UCEC	RSPRY1 →	+0.716	+3.346	.001	.005	3	1
UCEC	TMEM183A →	+0.578	+3.459	.007	.005	3	1
UCEC	EN2 →	+2.963	+3.364	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 197 associations by consensus.

CXADR by CDKN1C expression — UCEC

Explore this box plot interactively →