CDKN1C

Across TCGA pan-cancer cohorts, CDKN1C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CDKN1C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDKN1C RNA is repressed in tumor relative to normal tissue. In most cancer types CDKN1C is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where CDKN1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDKN1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.717	<.001	12	view →
KICH	Female	III,IV	−4.313	<.001	11	view →
KIRP	Male	III,IV	−3.267	<.001	11	view →
LUAD	Female	III,IV	−1.411	<.001	9	view →
BLCA	All	All	−1.303	<.001	7	view →
THCA	All	All	−0.462	<.001	7	view →
BRCA	All	II,III,IV	−2.272	<.001	6	view →
LUSC	Male	All	−1.155	<.001	6	view →
CHOL	All	All	+1.616	.001	4	view →
STAD	All	All	−0.898	.004	4	view →
UCEC	All	All	−0.895	.023	2	view →
PRAD	All	All	−0.894	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CDKN1C–KIRC

Open the KIRC breakdown →