CDKN1A

Across TCGA patient cohorts, CDKN1A protein abundance is significantly associated with the RNA expression of many other genes, with 2,862 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKN1A-associated genes across cancer lineages are PTCHD4, WDR88, and ZNF573. Each is linked with CDKN1A in more than 3 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKN1A versus PTCHD4 in CCRCC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTCHD4 →	+1.095	+0.789	.002	<.001	3	4
UCEC	WDR88 →	-0.535	-0.458	<.001	.001	3	4
HNSC	ZNF573 →	-0.452	-0.385	.007	.001	3	4
CCRCC	EDA2R →	+1.043	+0.902	.004	.003	3	3
HNSC	PBX1 →	-0.807	-0.433	<.001	<.001	3	3
UCEC	PBX1-AS1 →	-0.794	-0.586	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,862 associations by consensus.

CDKN1A vs PTCHD4 — CCRCC

Explore this scatter interactively →