CDKN1A

Across TCGA pan-cancer cohorts, CDKN1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CDKN1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDKN1A RNA is repressed in tumor relative to normal tissue. In most cancer types CDKN1A is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where CDKN1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDKN1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.276	<.001	10	view →
HNSC	All	All	+0.776	<.001	9	view →
THCA	Male	All	+1.647	<.001	8	view →
KIRC	All	All	+1.077	<.001	8	view →
KIRP	Female	II,III,IV	+2.645	<.001	7	view →
KICH	All	II,III,IV	−1.510	.003	6	view →
BLCA	All	All	−1.193	.003	6	view →
LUSC	Male	II,III,IV	−1.179	<.001	4	view →
LIHC	All	III,IV	+1.131	.004	4	view →
PRAD	All	All	−0.525	.014	2	view →
LUAD	All	All	−0.477	.002	2	view →
BRCA	All	All	−0.329	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CDKN1A–COAD

Open the COAD breakdown →