CDK5

Across TCGA patient cohorts, CDK5 mutation is significantly associated with the RNA expression of many other genes, with 895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5-associated genes across cancer lineages are RPL5P31, MTDHP5, and RNA5SP248. Each is linked with CDK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5-to-partner and partner-to-CDK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL5P31 grouped by CDK5-low versus CDK5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5→partner) and Y-score (partner→CDK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL5P31 →	+0.129	+4.787	<.001	.003	3	2
HNSC	MTDHP5 →	+0.061	+4.655	<.001	.007	3	2
SKCM	RNA5SP248 →	+0.237	+3.045	.002	.008	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
HNSC	RNU6-1181P →	+0.388	+5.008	<.001	.004	3	1
HNSC	RNU6-1226P →	+0.315	+4.505	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 895 associations by consensus.

RPL5P31 by CDK5 expression — LUAD

Explore this box plot interactively →