CDK5

Across TCGA pan-cancer cohorts, CDK5 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CDK5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDK5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDK5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where CDK5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.174	<.001	12	view →
HNSC	Male	IV	+1.084	<.001	12	view →
KIRC	Female	IV	+0.821	<.001	12	view →
BLCA	Female	All	+1.362	<.001	11	view →
LIHC	Female	II,III,IV	+1.501	<.001	9	view →
LUAD	Female	III,IV	+1.095	<.001	9	view →
KIRP	Male	II,III,IV	+0.981	<.001	9	view →
LUSC	Female	II,III,IV	+0.978	<.001	9	view →
STAD	All	II,III,IV	+0.943	<.001	8	view →
UCEC	All	III,IV	+1.476	<.001	6	view →
BRCA	All	III,IV	+1.276	<.001	6	view →
CHOL	Male	All	+1.988	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CDK5–COAD

Open the COAD breakdown →