CDK15

Across TCGA patient cohorts, CDK15 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK15-associated genes across cancer lineages are Cyclin-E2, FoxM1, and mTOR_pS2448. Each is linked with CDK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK15-to-partner and partner-to-CDK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CDK15-low versus CDK15-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK15→partner) and Y-score (partner→CDK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E2 →	+0.159	+2.824	.042	.036	3	3
UCEC	FoxM1 →	+0.249	+2.115	.027	.019	3	2
UCEC	mTOR_pS2448 →	-0.204	-3.308	.001	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.693	-3.584	<.001	.002	3	2
UCEC	AMPK_alpha →	-0.203	-3.584	.014	.002	3	2
UCEC	STAT3_pY705 →	-0.512	-2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-E2 by CDK15 expression — LUAD

Explore this box plot interactively →