CDK11B

Across TCGA patient cohorts, CDK11B RNA expression is significantly associated with the mutation status of many other genes, with 9,588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK11B-associated genes across cancer lineages are TP53, FLG, and NRXN1. Each is linked with CDK11B in more than 9 cancer types. Because this analysis shows association rather than direction, both CDK11B-to-partner and partner-to-CDK11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by CDK11B-low versus CDK11B-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11B→partner) and Y-score (partner→CDK11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+2.121	+0.448	<.001	<.001	3	10
SKCM	FLG →	+1.156	+0.171	<.001	.001	3	6
SKCM	NRXN1 →	+1.311	+0.181	.003	.004	3	5
SKCM	SORCS1 →	+2.127	+0.343	<.001	<.001	3	4
CESC	LRP1 →	+3.634	+0.382	.001	.004	3	4
UCEC	PATJ →	+2.102	+0.379	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,588 associations by consensus.

TP53 by CDK11B expression — SKCM

Explore this box plot interactively →