CDK11B

Across TCGA pan-cancer cohorts, CDK11B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CDK11B data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CDK11B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CDK11B expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

ACC, LGG, and KICH are the cancer types where CDK11B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.769	0.967	<.001	65	view →
LGG	DFS	Median	All	0.622	0.854	<.001	54	view →
KICH	OS	Tertile	All	0.800	1.000	.011	31	view →
LUSC	DFS	Tertile	III,IV	0.391	0.961	.004	31	view →
LIHC	DFS	Tertile	All	0.413	0.577	.001	31	view →
LAML	DFS	Tertile	All	0.394	0.675	<.001	30	view →
UCS	DFS	Tertile	II,III,IV	0.543	0.198	.014	26	view →
CHOL	DFS	Median	All	0.805	0.114	<.001	25	view →
GBM	DFS	Tertile	All	0.402	0.148	.001	22	view →
COAD	DFS	Quartile	All	0.618	0.796	.001	18	view →
HNSC	DFS	Quartile	IV	0.598	0.322	.005	16	view →
PAAD	OS	Tertile	All	0.515	0.750	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CDK11B–ACC (OS)

Open the ACC breakdown →