CDHR3

Across TCGA cell cohorts, CDHR3 mutation is significantly associated with the mutation status of many other genes, with 3,101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDHR3-associated genes across cancer lineages are VPS13B, PHF14, and SLC4A3. Each is linked with CDHR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDHR3-to-partner and partner-to-CDHR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS13B grouped by CDHR3-low versus CDHR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDHR3→partner) and Y-score (partner→CDHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VPS13B →	+2.167	+3.017	.003	.003	1	4
BONE	PHF14 →	+5.437	+5.437	.003	.003	1	3
BONE	SLC4A3 →	+4.437	+5.000	.007	.007	1	3
BONE	WDR44 →	+4.437	+5.000	.007	.007	1	3
BONE	ADGRF3 →	+5.437	+5.437	.003	.003	1	3
BONE	MGAM →	+5.437	+5.437	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

VPS13B by CDHR3 expression — BLOOD_Leukemia

Explore this box plot interactively →