CDHR3

Across TCGA pan-cancer cohorts, CDHR3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CDHR3 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CDHR3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDHR3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

UVM, ACC, and KICH are the cancer types where CDHR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.325	0.692	<.001	125	view →
ACC	DFS	Median	All	0.267	0.649	<.001	105	view →
KICH	OS	Median	II,III,IV	0.632	0.960	.003	69	view →
BRCA	OS	Median	All	0.944	0.904	.002	59	view →
BLCA	OS	Tertile	All	0.384	0.626	.003	49	view →
UCS	OS	Median	IV	0.732	0.224	.018	36	view →
SCLC	OS	Median	All	0.540	1.000	.001	32	view →
COAD	DFS	Tertile	II,III,IV	0.384	0.603	.003	31	view →
KIRP	DFS	Quartile	All	0.934	0.531	.001	30	view →
LUSC	OS	Median	All	0.723	0.625	.005	30	view →
MESO	OS	Median	II,III,IV	0.302	0.492	.008	26	view →
LGG	DFS	Tertile	All	0.725	0.855	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CDHR3–UVM (DFS)

Open the UVM breakdown →