CDH3

Across TCGA patient cohorts, CDH3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,293 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CDH3-associated genes across cancer lineages are HSPE1P5, CYP27C1, and GJB3. Each is linked with CDH3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH3-to-partner and partner-to-CDH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDH3 versus HSPE1P5 in LSCC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH3→partner) and Y-score (partner→CDH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HSPE1P5 →	+0.906	+0.674	<.001	<.001	3	6
HNSC	CYP27C1 →	+0.938	+0.534	<.001	<.001	3	5
BRCA	GJB3 →	+1.414	+0.820	<.001	<.001	3	5
BRCA	LIN7A →	-1.012	-0.675	<.001	<.001	3	4
HNSC	GLCCI1 →	-0.695	-0.448	<.001	<.001	3	4
CCRCC	CYP3A4 →	-1.101	-1.053	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,293 associations by consensus.

CDH3 vs HSPE1P5 — LSCC

Explore this scatter interactively →