CDH3

Across TCGA pan-cancer cohorts, CDH3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CDH3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDH3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDH3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where CDH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+5.248	<.001	12	view →
KIRC	Female	IV	−3.070	<.001	12	view →
HNSC	Male	All	+2.359	<.001	12	view →
THCA	All	IV	+4.112	<.001	11	view →
KIRP	Female	All	−3.114	<.001	11	view →
LUSC	Female	II,III,IV	+4.180	<.001	9	view →
LUAD	Female	II,III,IV	+3.101	<.001	9	view →
KICH	Male	II,III,IV	−2.841	<.001	8	view →
BLCA	All	III,IV	+2.709	<.001	8	view →
READ	Female	All	+4.019	<.001	7	view →
BRCA	Female	All	−0.750	.002	6	view →
STAD	Male	All	+2.478	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CDH3–COAD

Open the COAD breakdown →