CDH3

Across TCGA cell cohorts, CDH3 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH3-associated genes across cancer lineages are IQCJ, KRTAP5-4, and ZP2. Each is linked with CDH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH3-to-partner and partner-to-CDH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCJ grouped by CDH3-low versus CDH3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH3→partner) and Y-score (partner→CDH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IQCJ →	+0.029	+4.017	.003	.007	3	1
OESOPHAGUS	KRTAP5-4 →	+0.026	+4.017	.001	.007	3	1
BLOOD_Leukemia	ZP2 →	+0.091	+2.824	<.001	.007	3	1
BLOOD_Leukemia	MC3R →	+0.008	+3.984	<.001	.006	3	1
BLOOD_Leukemia	FAM71F1 →	+0.165	+3.736	<.001	.008	3	1
BLOOD_Leukemia	ODF1 →	+0.073	+4.752	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

IQCJ by CDH3 expression — OESOPHAGUS

Explore this box plot interactively →