CDH20

Across TCGA patient cohorts, CDH20 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH20-associated genes across cancer lineages are 4E-BP1_pT70, BRCA2, and Caspase-7-cleavedD198. Each is linked with CDH20 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH20-to-partner and partner-to-CDH20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by CDH20-low versus CDH20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH20→partner) and Y-score (partner→CDH20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.077	+1.222	.039	.035	3	5
STAD	BRCA2 →	-0.138	-2.563	.021	.010	3	3
STAD	Caspase-7-cleavedD198 →	+0.657	+3.169	.034	.018	2	4
UCEC	4E-BP1 →	+0.275	+3.584	.001	.002	3	3
LUAD	PI3K-p85 →	-0.192	-2.442	.042	.020	3	3
LUAD	Chk1 →	+0.371	+2.459	<.001	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

4E-BP1_pT70 by CDH20 expression — UCEC

Explore this box plot interactively →