CDH17

Across TCGA cell cohorts, CDH17 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH17-associated genes across cancer lineages are LYPD4, SCN10A, and C6orf118. Each is linked with CDH17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH17-to-partner and partner-to-CDH17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPD4 grouped by CDH17-low versus CDH17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH17→partner) and Y-score (partner→CDH17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LYPD4 →	+0.118	+4.867	<.001	.009	3	1
STOMACH	SCN10A →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	C6orf118 →	+0.146	+3.115	<.001	.004	3	1
LARGE_INTESTINE	RAMP3 →	+0.136	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OPN5 →	+0.017	+3.115	.006	.004	3	1
LARGE_INTESTINE	GUCY1A2 →	+0.118	+2.994	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

LYPD4 by CDH17 expression — BLOOD_Lymphoma

Explore this box plot interactively →