CDH17

Across TCGA pan-cancer cohorts, CDH17 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CDH17 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CDH17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDH17 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

UVM, HNSC, and KIRP are the cancer types where CDH17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.529	0.931	<.001	133	view →
HNSC	DFS	Median	All	0.772	0.648	.001	58	view →
KIRP	DFS	Tertile	II,III,IV	0.167	0.928	<.001	54	view →
UCS	DFS	Median	All	0.652	0.388	.007	36	view →
LUAD	DFS	Quartile	All	0.266	0.459	<.001	34	view →
MESO	DFS	Tertile	II,III,IV	0.330	0.679	.008	29	view →
ESCA	OS	Median	All	0.617	1.000	.009	18	view →
STAD	DFS	Median	III,IV	0.488	0.709	.021	12	view →
LIHC	OS	Median	All	0.723	0.836	.015	10	view →
PRAD	OS	Median	All	0.988	1.000	.023	8	view →
TGCT	DFS	Median	II,III,IV	0.772	1.000	.041	8	view →
OV	DFS	Quartile	All	0.474	0.582	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CDH17–UVM (DFS)

Open the UVM breakdown →