CDCA7

Across TCGA cell cohorts, CDCA7 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDCA7-associated genes across cancer lineages are SPACA5B, GPR6, and PRAMEF33. Each is linked with CDCA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDCA7-to-partner and partner-to-CDCA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA5B grouped by CDCA7-low versus CDCA7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDCA7→partner) and Y-score (partner→CDCA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPACA5B →	+0.021	+4.078	<.001	.009	3	1
LARGE_INTESTINE	GPR6 →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF33 →	+0.065	+3.700	<.001	.009	3	1
LARGE_INTESTINE	DGKK →	+0.290	+3.736	.001	.007	3	1
LARGE_INTESTINE	KCNS2 →	+0.085	+3.426	<.001	.007	2	1
LARGE_INTESTINE	CYYR1 →	+0.018	+3.426	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SPACA5B by CDCA7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →