CDC25B

Across TCGA patient cohorts, CDC25B mutation is significantly associated with the RNA expression of many other genes, with 2,112 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC25B-associated genes across cancer lineages are MED15P1, NF1P11, and IGLVIV-59. Each is linked with CDC25B in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC25B-to-partner and partner-to-CDC25B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED15P1 grouped by CDC25B-low versus CDC25B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC25B→partner) and Y-score (partner→CDC25B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MED15P1 →	+0.267	+4.466	<.001	.002	3	3
LUSC	NF1P11 →	+0.455	+3.652	<.001	.009	3	2
BLCA	IGLVIV-59 →	+0.410	+5.914	<.001	<.001	3	2
BLCA	MIR5680 →	+0.495	+5.018	<.001	.004	3	2
UCEC	MRPS11 →	+0.383	+2.500	.002	.001	3	2
UCEC	CIDECP1 →	+0.390	+2.544	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,112 associations by consensus.

MED15P1 by CDC25B expression — LUSC

Explore this box plot interactively →