CDC25B

Across TCGA patient cohorts, CDC25B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC25B-associated genes across cancer lineages are Rad50, Shc_pY317, and Src_pY527. Each is linked with CDC25B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC25B-to-partner and partner-to-CDC25B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CDC25B-low versus CDC25B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC25B→partner) and Y-score (partner→CDC25B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.215	-2.000	.049	.032	3	2
UCEC	Shc_pY317 →	-0.205	-2.459	.002	.019	3	2
UCEC	Src_pY527 →	-0.440	-2.000	.023	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.625	+3.189	.019	.010	3	2
UCEC	Di-Ras3 →	-0.147	-2.700	.028	.006	3	2
UCEC	ERK2 →	+0.282	+2.000	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Rad50 by CDC25B expression — UCEC

Explore this box plot interactively →