CDC23

Across TCGA patient cohorts, CDC23 mutation is significantly associated with the RNA expression of many other genes, with 2,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC23-associated genes across cancer lineages are RNU6-1047P, MIR7-3, and C14orf119. Each is linked with CDC23 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC23-to-partner and partner-to-CDC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1047P grouped by CDC23-low versus CDC23-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC23→partner) and Y-score (partner→CDC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1047P →	+0.412	+7.930	<.001	.008	3	2
CESC	MIR7-3 →	+0.370	+6.342	<.001	.001	3	2
UCEC	C14orf119 →	+0.331	+4.021	.005	<.001	3	2
UCEC	RCC1 →	+0.651	+3.748	<.001	<.001	3	2
UCEC	CFD →	+1.152	+4.000	<.001	<.001	3	2
UCEC	PRIM1 →	+0.893	+2.939	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,417 associations by consensus.

RNU6-1047P by CDC23 expression — LUAD

Explore this box plot interactively →