CDA

Across TCGA patient cohorts, CDA mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDA-associated genes across cancer lineages are CD8+ Tcm, Adipocytes, and DC. Each is linked with CDA in more than 1 cancer types. Because this analysis shows association rather than direction, both CDA-to-partner and partner-to-CDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by CDA-low versus CDA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDA→partner) and Y-score (partner→CDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD8+ Tcm →	+0.048	+5.177	.003	.007	3	1
UCEC	Adipocytes →	+0.024	+2.507	.008	.004	3	1
UCEC	DC →	+0.020	+2.082	.044	.038	3	1
UCEC	Hepatocytes →	+0.015	+2.343	.004	.020	3	1
UCEC	Pericytes →	+0.027	+2.113	.046	.013	3	1
UCEC	CLP →	-0.062	-2.279	.049	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ Tcm by CDA expression — BLCA

Explore this box plot interactively →