CDA

Across TCGA pan-cancer cohorts, CDA RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated CDA data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CDA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDA expression acts as an unfavorable survival marker, although some lineages such as ESCA and DLBC show a favorable association.

BLCA, ESCA, and PAAD are the cancer types where CDA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	IV	0.217	0.588	.002	52	view →
ESCA	OS	Median	III,IV	0.706	0.387	<.001	48	view →
PAAD	DFS	Quartile	All	0.195	0.529	<.001	43	view →
CESC	OS	Median	All	0.723	0.867	.001	38	view →
UVM	OS	Quartile	All	0.327	0.901	.012	30	view →
HNSC	OS	Tertile	All	0.727	0.839	.012	29	view →
UCS	DFS	Tertile	IV	0.488	0.936	.024	24	view →
LUAD	DFS	Median	All	0.247	0.476	<.001	22	view →
STAD	OS	Median	IV	0.176	0.511	.005	22	view →
KIRP	OS	Quartile	All	0.582	1.000	.005	18	view →
READ	DFS	Median	All	0.341	0.699	.003	15	view →
DLBC	DFS	Tertile	All	0.839	0.491	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

CDA–BLCA (DFS)

Open the BLCA breakdown →