CDA

Across TCGA pan-cancer cohorts, CDA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CDA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CDA RNA is repressed in tumor relative to normal tissue. In most cancer types CDA is over-expressed in tumor, although a few such as KIRP and LIHC show the opposite, repressed pattern.

KIRP, LUAD, and THCA are the cancer types where CDA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−3.188	<.001	11	view →
LUAD	All	III,IV	+2.431	<.001	9	view →
THCA	Male	All	+1.682	<.001	9	view →
LIHC	Male	II,III,IV	−2.263	<.001	8	view →
COAD	All	All	−1.122	<.001	6	view →
CHOL	All	All	−2.775	<.001	3	view →
KICH	All	IV	+1.757	.021	2	view →
LUSC	Male	II,III,IV	+1.196	.008	2	view →
READ	All	All	−1.561	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CDA–KIRP

Open the KIRP breakdown →