CD53

Across TCGA patient cohorts, CD53 mutation is significantly associated with the RNA expression of many other genes, with 2,416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD53-associated genes across cancer lineages are COPS8P1, GTF2H5, and LINC01995. Each is linked with CD53 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD53-to-partner and partner-to-CD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS8P1 grouped by CD53-low versus CD53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD53→partner) and Y-score (partner→CD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS8P1 →	+0.084	+2.356	<.001	<.001	3	2
UCEC	GTF2H5 →	+0.366	+1.786	.004	.008	3	2
COAD	LINC01995 →	+0.156	+4.418	<.001	.008	3	2
READ	RNU6-893P →	+0.733	+4.445	<.001	.005	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
READ	ANKRD20A6P →	+0.283	+4.925	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,416 associations by consensus.

COPS8P1 by CD53 expression — UCEC

Explore this box plot interactively →