CD4

Across TCGA patient cohorts, CD4 mutation is significantly associated with the RNA expression of many other genes, with 852 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD4-associated genes across cancer lineages are AQP7P3, SPRYD7P1, and RNU6-302P. Each is linked with CD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD4-to-partner and partner-to-CD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P3 grouped by CD4-low versus CD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD4→partner) and Y-score (partner→CD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P3 →	+0.024	+3.122	<.001	.001	3	2
BRCA	SPRYD7P1 →	+0.047	+4.683	.004	.005	3	2
BLCA	RNU6-302P →	+0.468	+4.396	<.001	.006	3	2
SKCM	RN7SL274P →	+0.108	+2.632	<.001	.002	3	2
SKCM	WDR81 →	+0.586	+3.208	.007	.009	3	2
LUAD	ZNF92P1Y →	+0.013	+5.757	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 852 associations by consensus.

AQP7P3 by CD4 expression — UCEC

Explore this box plot interactively →