CD4

Across TCGA pan-cancer cohorts, CD4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD4 is over-expressed in tumor, although a few such as LIHC and LUSC show the opposite, repressed pattern.

KIRC, LIHC, and LUSC are the cancer types where CD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.146	<.001	12	view →
LIHC	Male	III,IV	−1.816	<.001	8	view →
LUSC	Male	II,III,IV	−1.744	<.001	8	view →
THCA	All	III,IV	+0.938	.004	8	view →
LUAD	Male	All	−0.896	<.001	8	view →
COAD	All	All	−0.676	<.001	8	view →
STAD	All	II,III,IV	+1.269	<.001	7	view →
KIRP	All	All	+1.070	<.001	5	view →
BLCA	All	All	−0.858	.029	4	view →
HNSC	All	All	+0.590	.013	4	view →
CHOL	All	II,III,IV	−2.540	.003	2	view →
PAAD	All	All	−1.514	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CD4–KIRC

Open the KIRC breakdown →