CD4

Across TCGA cell cohorts, CD4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD4-associated genes across cancer lineages are SYCN, CFAP47, and BPIFB6. Each is linked with CD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD4-to-partner and partner-to-CD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCN grouped by CD4-low versus CD4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD4→partner) and Y-score (partner→CD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYCN →	+0.037	+4.539	<.001	.007	3	1
LARGE_INTESTINE	CFAP47 →	+0.357	+3.453	<.001	.009	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PNMA8C →	+0.007	+3.345	<.001	.007	3	1
BLOOD_Leukemia	TRPM3 →	+0.053	+4.295	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SYCN by CD4 expression — BLOOD_Leukemia

Explore this box plot interactively →